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Assuming the random effects are normally distributed with between-study standard deviation, then an approximate prediction interval for the factor-outcome association in an unspecified study can be obtained as. For example, for the factor par we found an odds ratio of 1. 45 (Model?1 using MLE) versus 1. 32 (Model?5 using MLE). Occasionally, differences led to the one-stage and two-stage models disagreeing upon statistical significance (e.